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Beyond its energy role, NAD+ is the essential substrate of sirtuins (SIRT1-SIRT7), deacetylases that regulate mitochondrial biogenesis, DNA repair, and resistance to cellular stress (Imai & Guarente, Trends Cell Biol 2014)

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At iThrive, we always recommend deeper testing first through Book a Root Cause Analysis when any of you stated unexplained B12 deficiency, ongoing fatigue, and digestive issues despite taking supplements